| First Author | Xin Y | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 3800 |
| PubMed ID | 32123231 | Mgi Jnum | J:293139 |
| Mgi Id | MGI:6407308 | Doi | 10.1038/s41598-020-60728-6 |
| Citation | Xin Y, et al. (2020) PET imaging of medulloblastoma with an (18)F-labeled tryptophan analogue in a transgenic mouse model. Sci Rep 10(1):3800 |
| abstractText | In vivo positron emission tomography (PET) imaging is a key modality to evaluate disease status of brain tumors. In recent years, tremendous efforts have been made in developing PET imaging methods for pediatric brain tumors. Carbon-11 labelled tryptophan derivatives are feasible as PET imaging probes in brain tumor patients with activation of the kynurenine pathway, but the short half-life of carbon-11 limits its application. Using a transgenic mouse model for the sonic hedgehog (Shh) subgroup of medulloblastoma, here we evaluated the potential of the newly developed 1-(2-[(18)F]fluoroethyl)-L-tryptophan (1-L-[(18)F]FETrp) as a PET imaging probe for this common malignant pediatric brain tumor. 1-L-[(18)F]FETrp was synthesized on a PETCHEM automatic synthesizer with good chemical and radiochemical purities and enantiomeric excess values. Imaging was performed in tumor-bearing Smo/Smo medulloblastoma mice with constitutive actvation of the Smoothened (Smo) receptor using a PerkinElmer G4 PET-X-Ray scanner. Medulloblastoma showed significant and specific accumulation of 1-L-[(18)F]FETrp. 1-L-[(18)F]FETrp also showed significantly higher tumor uptake than its D-enantiomer, 1-D-[(18)F]FETrp. The uptake of 1-L-[(18)F]FETrp in the normal brain tissue was low, suggesting that 1-L-[(18)F]FETrp may prove a valuable PET imaging probe for the Shh subgroup of medulloblastoma and possibly other pediatric and adult brain tumors. |
