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Allele : Nbn<tm3Jpt> nibrin; targeted mutation 3, John H J Petrini

Primary Identifier	MGI:3831174	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Nbn
Transmission	Germline	Strain of Origin	129/Sv
Is Recombinase	false	Is Wild Type	false

molecularNote

The targeting vector used to create Nbn^tm1Jpt was used in embryonic stem cells containing Nbn^tm2.1Jpt to create an allele that coded for amino acids 221 to 727. The predicted protein lacks the FHA, BRCT and ATM-interacting domains.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Nbn<deltaBC>,
Nbn<deltaBC>

earliestPublication:
Shull ER, et al. (2009) Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev 23(2):171-80

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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