| First Author | Zhu G | Year | 2001 |
| Journal | J Immunol | Volume | 167 |
| Issue | 5 | Pages | 2671-6 |
| PubMed ID | 11509610 | Mgi Jnum | J:132372 |
| Mgi Id | MGI:3775858 | Doi | 10.4049/jimmunol.167.5.2671 |
| Citation | Zhu G, et al. (2001) Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice. J Immunol 167(5):2671-6 |
| abstractText | Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Ealpha promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220(+) B cells accompanied with low levels of circulating IgG and defective humoral responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide stimulation for allogeneic T cells in both lymphoproliferative and CTL responses in vitro, whereas their T cells remain functionally normal. Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation. |
