| Primary Identifier | MGI:3832514 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Orai1 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| description | ES cell line = B6/3 |
| molecularNote | Exon 1 was replaced with one in which a C to T transition results in an amino acid substitution of tryptophan for arginine at position 93 (R93W). A self-excising neo cassette was inserted downstream of exon 1 and was subsequently removed. This amino acid substitution mimic the one identified in human SCID patients that abrogates store-operated calcium entry and calcium release-activated channel currents. |
