Primary Identifier | MGI:3834666 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inducible, Inserted expressed sequence, Reporter | Gene | Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer |
Strain of Origin | FVB/N | Induced With | doxycycline/tetracycline |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The human gene from a patient with Hutchinson-Gilford progeria syndrome, in which a nucleotide substitution (1824C>T; G608G) activates a cryptic splice site, was inserted downstream of a tetracycline promoter and upstream of an IRES-EGFP. Eight lines were created. |