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Allele : Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer transgene insertion VF1-07, Maria Eriksson

Primary Identifier  MGI:3834666 Allele Type  Transgenic
Attribute String  Humanized sequence, Inducible, Inserted expressed sequence, Reporter Gene  Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer
Strain of Origin  FVB/N Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  The human gene from a patient with Hutchinson-Gilford progeria syndrome, in which a nucleotide substitution (1824C>T; G608G) activates a cryptic splice site, was inserted downstream of a tetracycline promoter and upstream of an IRES-EGFP. Eight lines were created.
  • mutations:
  • Insertion
  • synonyms:
  • tetop-LA<G608G>,
  • tetop-LA<G608G>
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

14 Publication categories