| Primary Identifier | MGI:3834570 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(ATN1*)Q129Stsu |
| Transmission | Germline | Strain of Origin | 129S/SvEv-Gpi1<c> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The transgene was engineered from BAC DRPLA18E that contains the human gene for ATN1 from a patient with dentatorubral-pallidoluysian atrophy (DRPLA) with a 76 CAG trinucleotide repeat within the gene. During maintenance of Tg(ATN1*)Drm21Stsu a mosaic mouse was isolated contained a combination of cells with 76 CAG repeats and 129 CAG repeats within the transgene. This mouse was bred to produce a line with the mutant human ATN1 with 129 CAG repeats. |
