| First Author | Lee K | Year | 2019 |
| Journal | Cell Rep | Volume | 29 |
| Issue | 8 | Pages | 2438-2449.e4 |
| PubMed ID | 31747611 | Mgi Jnum | J:283306 |
| Mgi Id | MGI:6386100 | Doi | 10.1016/j.celrep.2019.10.060 |
| Citation | Lee K, et al. (2019) Gain Modulation by Corticostriatal and Thalamostriatal Input Signals during Reward-Conditioned Behavior. Cell Rep 29(8):2438-2449.e4 |
| abstractText | The cortex and thalamus send excitatory projections to the striatum, but little is known about how these inputs, either individually or collectively, regulate striatal dynamics during behavior. The lateral striatum receives overlapping input from the secondary motor cortex (M2), an area involved in licking, and the parafascicular thalamic nucleus (PF). Using neural recordings, together with optogenetic terminal inhibition, we examine the contribution of M2 and PF projections on medium spiny projection neuron (MSN) activity as mice performed an anticipatory licking task. Each input has a similar contribution to striatal activity. By comparing how suppressing single or multiple projections altered striatal activity, we find that cortical and thalamic input signals modulate MSN gain and that this effect is more pronounced in a temporally specific period of the task following the cue presentation. These results demonstrate that cortical and thalamic inputs synergistically regulate striatal output during reward-conditioned behavior. |
