| First Author | Chan RW | Year | 2022 |
| Journal | Neuroimage | Volume | 263 |
| Pages | 119640 | PubMed ID | 36176220 |
| Mgi Jnum | J:350181 | Mgi Id | MGI:7662459 |
| Doi | 10.1016/j.neuroimage.2022.119640 | Citation | Chan RW, et al. (2022) Distinct local and brain-wide networks are activated by optogenetic stimulation of neurons specific to each layer of motor cortex. Neuroimage 263:119640 |
| abstractText | Primary motor cortex (M1) consists of a stack of interconnected but distinct layers (L1-L6) which affect motor control through large-scale networks. However, the brain-wide functional influence of each layer is poorly understood. We sought to expand our knowledge of these layers' circuitry by combining Cre-driver mouse lines, optogenetics, fMRI, and electrophysiology. Neuronal activities initiated in Drd3 neurons (within L2/3) were mainly confined within M1, while stimulation of Scnn1a, Rbp4, and Ntsr1 neurons (within L4, L5, and L6, respectively) evoked distinct responses in M1 and motor-related subcortical regions, including striatum and motor thalamus. We also found that fMRI responses from targeted stimulations correlated with both local field potentials (LFPs) and spike changes. This study represents a step forward in our understanding of how different layers of primary motor cortex are embedded in brain-wide circuitry. |
