| First Author | Pauzin FP | Year | 2018 |
| Journal | Cell Rep | Volume | 23 |
| Issue | 5 | Pages | 1314-1325 |
| PubMed ID | 29719247 | Mgi Jnum | J:283476 |
| Mgi Id | MGI:6385934 | Doi | 10.1016/j.celrep.2018.03.128 |
| Citation | Pauzin FP, et al. (2018) A Corticothalamic Circuit for Refining Tactile Encoding. Cell Rep 23(5):1314-1325 |
| abstractText | A fundamental task for the brain is to determine which aspects of the continuous flow of information is the most relevant in a given behavioral situation. The information flow is regulated via dynamic interactions between feedforward and feedback pathways. One such pathway is via corticothalamic feedback. Layer 6 (L6) corticothalamic (CT) cells make both cortical and thalamic connections and, therefore, are key modulators of activity in both areas. The functional properties of L6 CT cells in sensory processing were investigated in the mouse whisker system. Optogenetic activation of L6 CT neurons decreased spontaneous spiking, with the net effect that a whisker-evoked response was more accurately detected (larger evoked-to-spontaneous spiking ratio) but at the expense of reducing the response probability. In addition, L6 CT activation decreases sensory adaptation in both the thalamus and cortex. L6 CT activity can thus tune the tactile system, depending on the behaviorally relevant tactile input. |
