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Allele : Mre11a<tm2.1Dof> MRE11A homolog A, double strand break repair nuclease; targeted mutation 2.1, David O Ferguson

Primary Identifier	MGI:3839939	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Mre11a
Transmission	Germline	Strain of Origin	Not Specified
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was inserted upstream of exon 5, and a floxed neo cassette was inserted downstream of exon 5. Germ line, cre mediated recombination was used to remove the neo cassette.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Mre11<Cond>,
Mre11<Cond>

earliestPublication:
Buis J, et al. (2008) Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 135(1):85-96

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

7 Publication categories

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