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Allele : Map4k2<tm1Jmky> mitogen-activated protein kinase kinase kinase kinase 2; targeted mutation 1, John M Kyriakis

Primary Identifier	MGI:3840555	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Map4k2
Transmission	Germline	Strain of Origin	129
Is Recombinase	false	Is Wild Type	false

molecularNote

The genomic sequence spanning most of exon 1 through exon 22 was replaced with a STOP/neo cassette. The absence of protein expression in bone marrow macrophages and peripheral blood leukocytes.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Gck<->,
Gck<->

earliestPublication:
Zhong J, et al. (2009) GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38. (RETRACTED Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5134). Proc Natl Acad Sci U S A 106(11):4372-7

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

4 Publication categories

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