Other
16 Authors
- Saito K,
- Valencia-Torres L,
- Shu G,
- Wang C,
- Myers MG Jr,
- He Y,
- Yang Y,
- Xu P,
- Xu Y,
- Yan X,
- Tong Q,
- Hinton A Jr,
- Zhu L,
- Heisler LK,
- Cao X,
- Wu Q
| First Author | Xu P | Year | 2017 |
| Journal | Biol Psychiatry | Volume | 81 |
| Issue | 9 | Pages | 737-747 |
| PubMed ID | 27516377 | Mgi Jnum | J:284437 |
| Mgi Id | MGI:6381196 | Doi | 10.1016/j.biopsych.2016.06.005 |
| Citation | Xu P, et al. (2017) Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice. Biol Psychiatry 81(9):737-747 |
| abstractText | BACKGROUND: Neural networks that regulate binge eating remain to be identified, and effective treatments for binge eating are limited. METHODS: We combined neuroanatomic, pharmacologic, electrophysiological, Cre-lox, and chemogenetic approaches to investigate the functions of 5-hydroxytryptamine (5-HT) 2C receptor (5-HT2CR) expressed by dopamine (DA) neurons in the regulation of binge-like eating behavior in mice. RESULTS: We showed that 5-HT stimulates DA neural activity through a 5-HT2CR-mediated mechanism, and activation of this midbrain 5-HT-->DA neural circuit effectively inhibits binge-like eating behavior in mice. Notably, 5-HT medications, including fluoxetine, d-fenfluramine, and lorcaserin (a selective 5-HT2CR agonist), act on 5-HT2CRs expressed by DA neurons to inhibit binge-like eating in mice. CONCLUSIONS: We identified the 5-HT2CR population in DA neurons as one potential target for antibinge therapies, and provided preclinical evidence that 5-HT2CR agonists could be used to treat binge eating. |
