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Allele : Il6st<tm4Thir> interleukin 6 signal transducer; targeted mutation 4, Toshio Hirano
Primary Identifier  MGI:3843614 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Il6st
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  cDNA encoding the transmembrane and cytoplasmic domains of human IL6ST replaced the corresponding sequence of the mouse locus, yielding a mouse-human chimeric protein. The expression levels of the chimeric protein in homozygote B and T cells was similar to expression levels of endogenous protein in wild-type controls.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • gp130<H>,
  • gp130<H>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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