Primary Identifier | MGI:3843671 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(ACTB-TNFRSF6B)754Jwu |
Strain of Origin | C3H x C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
description | Line 17139 exhibits a phenotype similar to Line 754, including lymphadenopathy, pathologies in skin, kidney and liver and a shortened lifespan in females. |
molecularNote | The construct consists of human full length Dcr3 (TNFRSF6B) cDNA flanked by human beta actin promoter and beta actin poly(A) signal. The construct was injected into fertilized eggs from C3H x C57BL/6 mice. Line 754 was established and analyzed further. |