| First Author | Carissimo G | Year | 2019 |
| Journal | Life Sci Alliance | Volume | 2 |
| Issue | 1 | PubMed ID | 30665948 |
| Mgi Jnum | J:287946 | Mgi Id | MGI:6391864 |
| Doi | 10.26508/lsa.201900298 | Citation | Carissimo G, et al. (2019) Viperin controls chikungunya virus-specific pathogenic T cell IFNgamma Th1 stimulation in mice. Life Sci Alliance 2(1) |
| abstractText | Chikungunya virus (CHIKV) has been a worldwide threat since its reemergence in La Reunion Island in 2004. Expression of the interferon-stimulated protein Viperin correlates with viral load burden in patients, and studies in mice have demonstrated its role to limit disease severity against CHIKV infection. Using Viperin (-/-) mice, we aimed to understand the contribution of Viperin to the T-cell immune response against CHIKV. CD4 T-cell depletion in Viperin (-/-) mice showed that increased late acute joint inflammation (5-8 d postinfection) was exclusively mediated by T cells. Specifically, CHIKV-infected Viperin (-/-) mice showed an increased INFgamma Th1 profile of CD4 T cells, enhanced INFgamma stimulation by APCs, an increased INFgamma secretion profile in the joint microenvironment, and increased numbers of inflammatory monocytes in virus-infected joints compared with WT mice. Bone marrow grafting experiments showed that Viperin expression in both hematopoietic and non-hematopoietic cells is instrumental in reducing disease severity associated with a CD4 T-cell response. |
