| First Author | Lafont D | Year | 2009 |
| Journal | Behav Brain Res | Volume | 201 |
| Issue | 1 | Pages | 29-40 |
| PubMed ID | 19428613 | Mgi Jnum | J:148388 |
| Mgi Id | MGI:3844741 | Doi | 10.1016/j.bbr.2009.01.025 |
| Citation | Lafont D, et al. (2009) A novel role for receptor like protein tyrosine phosphatase zeta in modulation of sensorimotor responses to noxious stimuli: evidences from knockout mice studies. Behav Brain Res 201(1):29-40 |
| abstractText | Receptor like protein tyrosine phosphatase zeta (RPTPz) (also known as RPTPbeta or PTPxi) is a tyrosine phosphatase widely expressed in the nervous system, thought to play a role in cell-cell communication. However, knocking out RPTPz does not induce major neural abnormalities in mice. In order to better assess the potential role of RPTPz in various neural functions, we performed a comprehensive behavioural characterization of CNS/PNS functions in knockout mice (RPTPz -/-) confirming previously observed impaired working memory functions and further demonstrating an altered motor coordination. Moreover, RPTPz -/- mice displayed reduced responses to moderate thermal and tactile stimuli, both in baseline and under inflammatory conditions. These findings assign novel functional role of RPTPz in motor coordination and nociception. |
