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Allele : Tg(KRT5-Nfkbia*)3Rto transgene insertion 3, Rune Toftgard

Primary Identifier  MGI:3844945 Allele Type  Transgenic
Attribute String  Dominant negative, Inserted expressed sequence Gene  Tg(KRT5-Nfkbia*)3Rto
Strain of Origin  (CBA x C57BL/6)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  The bovine promoter was used to drive epidermis-specific expression of a mutated cDNA with nucleotide substitutions leading to amino acid substitutions of glycine for serine at positions 32 and alanine for serine at position 36. These mutations create a super-repressor version that is resistant to phosphorylation and degradation. Seven founders were created and line 3 was selected as the representative line.
  • mutations:
  • Insertion
  • synonyms:
  • K5-IkappaBalphaSR,
  • K5-IkappaBalphaSR
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories