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Allele : Hdac2<tm1.2Rdp> histone deacetylase 2; targeted mutation 1.2, Ronald DePinho

Primary Identifier  MGI:3844984 Allele Type  Targeted
Attribute String  Null/knockout Gene  Hdac2
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Is Recombinase  false Is Wild Type  false
molecularNote  LoxP sites were inserted upstream of exon 5 and downstream of exon 6. Mice carrying this allele were crossed with mice expressing cre recombinase in the germline. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of homozygote brain extracts. The same analysis showed that expression of related Hdac1 protein was upregulated.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • HDAC2KO,
  • HDAC2KO
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

6 Publication categories