| First Author | Park SH | Year | 2014 |
| Journal | Scand J Immunol | Volume | 80 |
| Issue | 3 | Pages | 191-7 |
| PubMed ID | 24965518 | Mgi Jnum | J:327770 |
| Mgi Id | MGI:6872822 | Doi | 10.1111/sji.12203 |
| Citation | Park SH, et al. (2014) Spin90 deficiency increases CXCL13-mediated B cell migration. Scand J Immunol 80(3):191-7 |
| abstractText | SPIN90 regulates actin dynamics, which is important for cell migration control. CXCL13-mediated B cell migration is essential for B cell immune responses. In this study, we investigated the role of SPIN90 in CXCL13-mediated B cell migration using Spin90 gene-deficient mice. Our chemokinesis analysis and transwell cell migration assay showed that SPIN90 is involved in CXCL13-mediated B cell migration. Moreover, the level of CXCR5, which is CXCL13 receptor, was increased in SPIN90-deficient B cells compared with wild-type B cells. Overall, our data suggest that SPIN90 plays an important role in B cell immune responses through the regulation of CXCL13-mediated B cell migration. |
