| First Author | Jiang T | Year | 2023 |
| Journal | Biochem Biophys Res Commun | Volume | 647 |
| Pages | 9-15 | PubMed ID | 36708662 |
| Mgi Jnum | J:333210 | Mgi Id | MGI:7433874 |
| Doi | 10.1016/j.bbrc.2023.01.053 | Citation | Jiang T, et al. (2023) MicroRNA-218 regulates neuronal radial migration and morphogenesis by targeting Satb2 in developing neocortex. Biochem Biophys Res Commun 647:9-15 |
| abstractText | Neuronal migration and morphogenesis are fundamental processes for cortical development. Their defects may cause abnormities in neural circuit formation and even neuropsychiatric disorders. Many proteins, especially layer-specific transcription factors and adhesion molecules, have been reported to regulate the processes. However, the involvement of non-coding RNAs in cortical development has not been extensively studied. Here, we identified microRNA-218 (miR-218) as a layer V-specific microRNA in mouse brains. Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia. We found in this study that miR-218 overexpression in developing mouse cortex led to severe defects in radial migration, morphogenesis, and spatial distribution of the cortical neurons. Moreover, we identified Satb2, an upper-layer marker, as a molecular target repressed by miR-218. These results suggest an underlying mechanism of miR-218 involvement in neuropsychiatric disorders, and the interactions of layer-specific non-coding RNAs and proteins in regulating cortical development. |
