| Primary Identifier | MGI:3849597 | Allele Type | Transgenic |
| Attribute String | Recombinase | Gene | Tg(Rr141-cre)1Ksec |
| Strain of Origin | Not Specified | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | The 3.4 kb transgene construct contained a 1.4 kb genomic fragment containing murine Hoxb2 rhombomere 4 (r4) enhancer Rr141 inserted upstream of the beta-globin promoter to drive expression of cre cDNA with a nuclear localization signal (NLS). Five founder lines were generated. Line 5 showed mosaic expression when crossed to R26R reporter animals, while the remaining 4 recapitulated the Hoxb2-r4 expression pattern as reported previously. Lines 3 and 4 showed higher background staining while line 1 showed stronger cre activity than line 2. Line 1 was used for subsequent analyses. |
