| First Author | Li Y | Year | 2009 |
| Journal | Nat Neurosci | Volume | 12 |
| Issue | 7 | Pages | 826-8 |
| PubMed ID | 19503083 | Mgi Jnum | J:149135 |
| Mgi Id | MGI:3847799 | Doi | 10.1038/nn.2349 |
| Citation | Li Y, et al. (2009) Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci 12(7):826-8 |
| abstractText | Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics. |
