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Allele : Glis3<tm1Amj> GLIS family zinc finger 3; targeted mutation 1, Anton M Jetten
Primary Identifier  MGI:3848053 Allele Type  Targeted
Attribute String  Null/knockout Gene  Glis3
Transmission  Germline Strain of Origin  129/Sv
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 4, which contains the sequence coding for zinc finger 5, and parts of intron 3 and 4 were replaced with a neo cassette. Deletion of zinc finger 5 (ZF5) is predicted to disrupt DNA binding ablity and transcriptional activity of the gene. The inability of the protein produced from this allele to activate transcription of a luciferase reporter with a Glis-binding site was confirmed by cellular assay.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Glis3<deltaZF5>,
  • Glis3<zf>,
  • Glis3<zf>,
  • Glis3<deltaZF5>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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8 Publication categories

Trail: Allele




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