| First Author | Hofmann SL | Year | 1988 |
| Journal | Science | Volume | 239 |
| Issue | 4845 | Pages | 1277-81 |
| PubMed ID | 3344433 | Mgi Jnum | J:127519 |
| Mgi Id | MGI:3763845 | Doi | 10.1126/science.3344433 |
| Citation | Hofmann SL, et al. (1988) Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science 239(4845):1277-81 |
| abstractText | A complementary DNA encoding the human low density lipoprotein (LDL) receptor under control of the mouse metallothionein-I promoter was injected into fertilized mouse eggs, and a strain of mice expressing high levels of LDL receptors was established. After administration of cadmium, these mice cleared intravenously injected 125I-labeled LDL from blood eight to ten times more rapidly than did normal mice. The plasma concentrations of apoproteins B-100 and E, the two ligands for the LDL receptor, declined by more than 90 percent after cadmium treatment, but the concentration of another apoprotein, A-I, was unaffected. Therefore, overexpression of an endocytotic receptor can dramatically lower the ambient concentration of its ligand in vivo. |
