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Allele : Angptl4<tm2Lex> angiopoietin-like 4; targeted mutation 2, Lexicon Pharmaceuticals

Primary Identifier  MGI:3849577 Allele Type  Targeted
Gene  Angptl4 Transmission  Germline
Strain of Origin  129S5/SvEvBrd Is Recombinase  false
Is Wild Type  false Project Collection  Lexicon
molecularNote  The codon encoding the glutamic acid at postion 40 was mutated by a G-to-A transition to instead code for lysine (E40K). A floxed neomycin cassette was included for targeting purposes and was subsequently removed by cre recombinase expression in ES cells. Mutant gene expression in homozygote liver and kidney was similar to endogenous levels as determined by RT-PCR analysis.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Angptl4<K>,
  • Angptl4<K>,
  • Angptl4<E40K>,
  • Angptl4<E40K>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories