| Primary Identifier | MGI:3849878 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Thrb |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Arginine codon 429 (CGG) in exon 10 was replaced with glutamine (CAG) (p.R429Q). This mutation disrupts the corepressor binding domain as well as homodimerization and has been identified in patients with central resistance to thyroid hormone. A self-excising ACN cassette (loxP site + testis-specific ACE promoter driven cre gene + neomycin resistance gene cassette + loxP site) was inserted into intron 9. |
