| Primary Identifier | MGI:3851106 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Foxp2 |
| Transmission | Germline | Strain of Origin | B6.Cg-Thy1<a> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 7 was replaced with a frt flanked neo cassette with a 5' loxP site and a modified exon 7 followed by a 3' loxP site. The modified exon 7 contains nucleotide substitutions that result in two amino acid substitutions, namely, asparagine for threonine at position 302 (T302N), and serine for asparagine at position 324 (N324S). These amino acid substitutions mimic the amino acids found in humans. Southern blot analysis revealed a duplication/rearrangement within the 3' portion of the gene. |
