| Primary Identifier | MGI:3851814 | Allele Type | Targeted |
| Attribute String | Conditional ready, No functional change | Gene | Hdac8 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | LoxP sites were inserted around exon 4 with a Frt-flanked neomycin cassette included between the exon and the downstream loxP site. Chimeric mice were bred with Flpe transgenic mice to remove the neomycin cassette, leaving exon 4 floxed. Cre-mediated deletion of exon 4 will eliminate part of the catalytic domain of the protein product and will also result in a frame shift upon fusion of exon 3 to exon 5. |
