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Allele : Il2<tm1.1Flv> interleukin 2; targeted mutation 1.1, Richard A Flavell

Primary Identifier  MGI:3852346 Allele Type  Targeted
Gene  Il2 Transmission  Germline
Strain of Origin  (129S1/SvImJ x NOD/ShiLtJ)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 1 through part of intron 2 was replaced with the corresponding sequence from C57BL/6 mice. Although the ES cells used to create this allele were (129S1/SvImJ x NOD/ShiLtJ)F1 the targeting event was mapped to the NOD allele. The floxed neo cassette downstream of the inserted sequence was removed by transient cre expression in ES cells.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • NOD.IL-2B6ex1,
  • NOD.IL-2B6ex1
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories