| First Author | Kurita N | Year | 2015 |
| Journal | Mol Immunol | Volume | 63 |
| Issue | 2 | Pages | 367-72 |
| PubMed ID | 25282043 | Mgi Jnum | J:222326 |
| Mgi Id | MGI:5644367 | Doi | 10.1016/j.molimm.2014.09.008 |
| Citation | Kurita N, et al. (2015) Increased serum IgA in Fcalpha/muR-deficient mice on the (129 x C57BL/6) F1 genetic background. Mol Immunol 63(2):367-72 |
| abstractText | Fcalpha/muR (CD351) is an Fc receptor for both IgA and IgM, which is abundantly expressed in the small intestine. However, the role of Fcalpha/muR in the intestinal tissue is largely unknown. Here, we found that Fcalpha/muR is highly expressed on follicular dendritic cells (FDCs) in Peyer's patches (PP) in the small intestine. Fcalpha/muR-deficient mice on the (129 x C57BL/6) F1 background showed increased serum, but not fecal, IgA level in response to gut-oriented antigens. IgA(+) B cells were increased in PP, but not in the lamina propria, of Fcalpha/muR-deficient mice, which was attenuated after reduction of commensal microbiota by oral treatment with antibiotics. Analyses of bone marrow chimeric mice, in which either FDCs or blood cells or both lack the expression of Fcalpha/muR, suggested that FDCs, but not blood cells, were responsible for the increased serum IgA concentration in Fcalpha/muR-deficient mice. Moreover, Fcalpha/muR-deficient mice showed enhanced germinal center formation against commensal microbiota in PP. Thus, serum IgA production against gut-oriented antigens is negatively regulated by Fcalpha/muR on FDCs in the F1 mice. |
