| First Author | Barro-Soria R | Year | 2019 |
| Journal | Sci Rep | Volume | 9 |
| Issue | 1 | Pages | 19622 |
| PubMed ID | 31873081 | Mgi Jnum | J:286521 |
| Mgi Id | MGI:6391835 | Doi | 10.1038/s41598-019-55380-8 |
| Citation | Barro-Soria R, et al. (2019) Angiotensin-Receptor-Associated Protein Modulates Ca(2+) Signals in Photoreceptor and Mossy Fiber cells. Sci Rep 9(1):19622 |
| abstractText | Fast, precise and sustained neurotransmission requires graded Ca(2+) signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca(2+) fluxes and Ca(2+) buffering in the presynaptic terminal that is not fully understood. Here, we show that the angiotensin-receptor-associated protein (ATRAP) localizes to synaptic terminals throughout the central nervous system. In the retinal photoreceptor synapse and the cerebellar mossy fiber-granule cell synapse, we find that ATRAP is involved in the generation of depolarization-evoked synaptic Ca(2+) transients. Compared to wild type, Ca(2+) imaging in acutely isolated preparations of the retina and the cerebellum from ATRAP knockout mice reveals a significant reduction of the sarcoendoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) activity. Thus, in addition to its conventional role in angiotensin signaling, ATRAP also modulates presynaptic Ca(2+) signaling within the central nervous system. |
