| First Author | Ben-Gigi L | Year | 2015 |
| Journal | eNeuro | Volume | 2 |
| Issue | 3 | PubMed ID | 26464987 |
| Mgi Jnum | J:229609 | Mgi Id | MGI:5752682 |
| Doi | 10.1523/ENEURO.0078-14.2015 | Citation | Ben-Gigi L, et al. (2015) Astrogliosis Induced by Brain Injury Is Regulated by Sema4B Phosphorylation(123). eNeuro 2(3):ENEURO.0078-14.2015 |
| abstractText | Injury to the CNS induces astrogliosis, an astrocyte-mediated response that has both beneficial and detrimental impacts on surrounding neural and non-neural cells. The precise signaling events underlying astrogliosis are not fully characterized. Here, we show that astrocyte activation was altered and proliferation was reduced in Semaphorin 4B (Sema4B)-deficient mice following injury. Proliferation of cultured Sema4B(-/-) astrocytes was also significantly reduced. In contrast to its expected role as a ligand, the Sema4B ectodomain was not able to rescue Sema4B(-/-) astrocyte proliferation but instead acted as an antagonist against Sema4B(+/-) astrocytes. Furthermore, the effects of Sema4B on astrocyte proliferation were dependent on phosphorylation of the intracellular domain at Ser825. Our results suggest that Sema4B functions as an astrocyte receptor, defining a novel signaling pathway that regulates astrogliosis after CNS injury. |
