| First Author | Ali M | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 17 | Pages | 2213-7 |
| PubMed ID | 26183206 | Mgi Jnum | J:226074 |
| Mgi Id | MGI:5695729 | Doi | 10.1016/j.febslet.2015.06.045 |
| Citation | Ali M, et al. (2015) LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFalpha-converting enzyme. FEBS Lett 589(17):2213-7 |
| abstractText | Tumor necrosis factor alpha (TNFalpha) is an inflammatory cytokine that plays an intimate role in septic shock. Injection of high levels of lipopolysaccharide induces septic shock and death in mice within 30 h, whereas ceramide synthase 2 (CerS2) null mice, defective in the synthesis of very-long acyl chain ceramides, die within approximately 10 h. The augmented rate of death of CerS2 null mice is due to elevated levels of TNFalpha secretion as a result of enhanced activity of TNFalpha-converting enzyme (TACE). We discuss the relationship between the sphingolipid acyl chain length and TACE activity and the relevance of this data to septic shock. |
