| First Author | Kim DE | Year | 2019 |
| Journal | Exp Neurobiol | Volume | 28 |
| Issue | 1 | Pages | 43-53 |
| PubMed ID | 30853823 | Mgi Jnum | J:284777 |
| Mgi Id | MGI:6391702 | Doi | 10.5607/en.2019.28.1.43 |
| Citation | Kim DE, et al. (2019) 14-3-3gamma Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors. Exp Neurobiol 28(1):43-53 |
| abstractText | 14-3-3gamma plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3gamma is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3gamma deficiency are largely unknown. Here, by using 14-3-3gamma deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3gamma heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3gamma levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3gamma heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms. |
