| First Author | Pai VJ | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 5 | Pages | e97637 |
| PubMed ID | 24836606 | Mgi Jnum | J:216334 |
| Mgi Id | MGI:5608653 | Doi | 10.1371/journal.pone.0097637 |
| Citation | Pai VJ, et al. (2014) Transgenic mice convert carbohydrates to essential fatty acids. PLoS One 9(5):e97637 |
| abstractText | Transgenic mice (named "Omega mice") were engineered to carry both optimized fat-1 and fat-2 genes from the roundworm Caenorhabditis elegans and are capable of producing essential omega-6 and omega-3 fatty acids from saturated fats or carbohydrates. When maintained on a high-saturated fat diet lacking essential fatty acids or a high-carbohydrate, no-fat diet, the Omega mice exhibit high tissue levels of both omega-6 and omega-3 fatty acids, with a ratio of approximately 1ratio1. This study thus presents an innovative technology for the production of both omega-6 and omega-3 essential fatty acids, as well as a new animal model for understanding the true impact of fat on human health. |
