Primary Identifier | MGI:4354599 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Tsc2 |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP and a loxP-neo-loxP cassette flanked exon 3 of Tsc2 which consists of 111 bp, encoding 37 amino acids near the N terminus of the protein (note that in some schemes this is counted as exon 4; however in accordance with human TSC2 gene, it is denoted this as exon 3, labeling a 5' untranslated exon as 1a). The neo cassette was removed in ES cells by transient cre expression leaving exon 3 floxed. |