| Primary Identifier | MGI:4359453 | Allele Type | Targeted |
| Gene | Pdx1 | Transmission | Germline |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Exon 2 was replaced with one in which nucleotide substitutions result in the amino acid substitution of serine with a STOP codon at position 210 (S210X). The modified exon was followed by a floxed neo cassette that was removed via germ line, cre mediated recombination. The predicted product lacks 74 amino acids of the C terminus. A 75% reduction in full-length expression was confirmed by western blot analysis on E13.5 pancreatic extracts. |
