| Primary Identifier | MGI:4356349 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Lrrk2 |
| Transmission | Germline | Strain of Origin | (C57BL/6 x 129)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 31 was replaced with one in which nucleotide substitutions led to the amino acid substitution of cysteine for arginine at position 1441 (R1441C), mimicking a mutation found in xome Parkinson's disease patients. A floxed neo cassette was inserted downstream of the modified exon and removed by transient cre expression in ES cells. |
