|  Help  |  About  |  Contact Us

Publication : Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.

First Author  Chen M Year  2016
Journal  Sci Rep Volume  6
Pages  31482 PubMed ID  27511108
Mgi Jnum  J:236918 Mgi Id  MGI:5810221
Doi  10.1038/srep31482 Citation  Chen M, et al. (2016) Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Sci Rep 6:31482
abstractText  Leucine Zipper-bearing Kinase (LZK/MAP3K13) is a member of the mixed lineage kinase family with high sequence identity to Dual Leucine Zipper Kinase (DLK/MAP3K12). While DLK is established as a key regulator of axonal responses to injury, the role of LZK in mammalian neurons is poorly understood. By gain- and loss-of-function analyses in neuronal cultures, we identify LZK as a novel positive regulator of axon growth. LZK signals specifically through MKK4 and JNKs among MAP2Ks and MAPKs respectively in neuronal cells, with JNK activity positively regulating LZK protein levels. Neuronal maturation or activity deprivation activates the LZK-MKK4-JNK pathway. LZK and DLK share commonalities in signaling, regulation, and effects on axon extension. Furthermore, LZK-dependent regulation of DLK protein expression and the lack of additive effects on axon growth upon co-manipulation suggest complex functional interaction and cross-regulation between these two kinases. Together, our data support the possibility for two structurally related MAP3Ks to work in concert to mediate axonal responses to external insult or injury in mammalian CNS neurons.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

7 Bio Entities

0 Expression