| First Author | Guo H | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 2346 |
| PubMed ID | 37095092 | Mgi Jnum | J:335194 |
| Mgi Id | MGI:7468177 | Doi | 10.1038/s41467-023-37797-y |
| Citation | Guo H, et al. (2023) Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice. Nat Commun 14(1):2346 |
| abstractText | The parasubthalamic nucleus (PSTN) is considered to be involved in motivation, feeding and hunting, all of which are highly depending on wakefulness. However, the roles and underlying neural circuits of the PSTN in wakefulness remain unclear. Neurons expressing calretinin (CR) account for the majority of PSTN neurons. In this study in male mice, fiber photometry recordings showed that the activity of PSTN(CR) neurons increased at the transitions from non-rapid eye movement (non-REM, NREM) sleep to either wakefulness or REM sleep, as well as exploratory behavior. Chemogenetic and optogenetic experiments demonstrated that PSTN(CR) neurons were necessary for initiating and/or maintaining arousal associated with exploration. Photoactivation of projections of PSTN(CR) neurons revealed that they regulated exploration-related wakefulness by innervating the ventral tegmental area. Collectively, our findings indicate that PSTN(CR) circuitry is essential for the induction and maintenance of the awake state associated with exploration. |
