Primary Identifier | MGI:4365738 | Allele Type | Targeted |
Attribute String | Inducible, Recombinase | Gene | Pvalb |
Transmission | Germline | Strain of Origin | C57BL/6 |
Induced With | tamoxifen | Is Recombinase | true |
Is Wild Type | false | Project Collection | Neuroscience Blueprint cre |
molecularNote | A targeting vector was designed to insert a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the Pvalb (parvalbumin; also called PV or Pva) gene. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background) to remove the neo selection cassette. |