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Allele : Tg(Col10a1-Tg*L2263P)1Rpbh transgene insertion 1, Raymond P Boot-Handford
Primary Identifier  MGI:4397570 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Col10a1-Tg*L2263P)1Rpbh
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The collagen X promoter was ligated upstream of the cDNA sequence encoding the myc-tagged cog mutant form (a C to T transition yielding a leucine to proline change at residue 2263) of thyroglobulin (Tg). This line has 5 copies of the transgene at a single insertion site and expressed 17% and 33% the level of endogenous collagen X in the hemizygous and homozygous state, respectively. Expression of Tg protein in hypertrophic chondrocytes did not affect the normal secretion of collagen X.
  • mutations:
  • Insertion
  • synonyms:
  • ColXTg<cog>,
  • ColXTg<cog>
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories





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