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Allele : Ret<tm1Ddg> ret proto-oncogene; targeted mutation 1, David D Ginty

Primary Identifier  MGI:4413350 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Ret
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
molecularNote  Exons 14 and 15 and an FRT-flanked neo cassette are flanked by loxP sites. A missense mutation in exon 15 changes valine 805 to alanine. This mutation is silent but sensitizes the protein to chemical inhibition of its kinase activity.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Ret<f>,
  • Ret<f>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

8 Publication categories