Primary Identifier | MGI:4414662 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Lrrk2 |
Transmission | Germline | Strain of Origin | 129X1/SvJ |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP site was inserted into intron 1 and an frt-flanked neo cassette with a second loxP site was inserted into intron 2. Cre mediated recombination removed the neo cassette and exon 2. The absence of protein expression was confirmed by western blot analysis on brain extracts. |