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Allele : Tg(Lck-tTA)1Doi transgene insertion 1, Christophe Benoist and Diane Mathis

Primary Identifier	MGI:4418667	Allele Type	Transgenic
Attribute String	Transactivator	Gene	Tg(Lck-tTA)1Doi
Strain of Origin	(C57BL/6 x SJL)F2	Is Recombinase	false
Is Wild Type	false

molecularNote

The Lck proximal promoter was used to drive expression of the TetR-VP16 transactivator (tTA). Several founder lines were produced with varying expression. This line expresses particularly in T cell lineages early in differentiation.

mutations:
Insertion

synonyms:
LTH1,
Tg(Lck-tTA)1Dim,
LTH1,
Tg(Lck-tTA)1Dim

earliestPublication:
Labrecque N, et al. (2001) How much TCR does a T cell need?. Immunity 15(1):71-82

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

3 Publication categories

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