| First Author | Correia-Neves M | Year | 1999 |
| Journal | J Immunol | Volume | 163 |
| Issue | 10 | Pages | 5471-7 |
| PubMed ID | 10553073 | Mgi Jnum | J:133108 |
| Mgi Id | MGI:3777734 | Doi | 10.4049/jimmunol.163.10.5471 |
| Citation | Correia-Neves M, et al. (1999) Amino acids specifying MHC class preference in TCR V alpha 2 regions. J Immunol 163(10):5471-7 |
| abstractText | Some TCR variable regions are preferentially expressed in CD4+ or CD8+ T cells, reflecting a predilection for interacting with MHC class II or class I molecules. The molecular basis for MHC class bias has been studied previously, in particular for V alpha 3 family members, pointing to a dominant role for two amino acid positions in complementary-determining regions (CDRs) 1 and 2. We have evaluated the generality of these findings by examining the MHC class bias of V alpha 2 family members, an attractive system because it shows more variability within the CDR1 and -2, exhibits variation in the framework regions, and includes a member for which the crystal structure has been determined. We find that preferential recognition of MHC class I or II molecules does not always depend on residues at the same positions of CDR1 and -2; rules for one family may be reversed in another. Instead, there are multiple influences exerted by various CDR1/2 positions as well as the CDR3s of both the TCR alpha- and TCR beta-chains. |
