| First Author | Jia X | Year | 2022 |
| Journal | Cell Rep | Volume | 41 |
| Issue | 6 | Pages | 111586 |
| PubMed ID | 36351404 | Mgi Jnum | J:332356 |
| Mgi Id | MGI:7386586 | Doi | 10.1016/j.celrep.2022.111586 |
| Citation | Jia X, et al. (2022) Divergent neurocircuitry dissociates two components of the stress response: glucose mobilization and anxiety-like behavior. Cell Rep 41(6):111586 |
| abstractText | Stress is a risk factor for emotion and energy metabolism disorders. However, the neurocircuitry mechanisms for emotion initiation and glucose mobilization underlying stress responses are unclear. Here we demonstrate that photoactivation of Gad2+ projection from the anterior bed nucleus of the stria terminalis (aBNST) to the arcuate nucleus (ARC) induces anxiety-like behavior as well as acute hyperglycemia. Photoinhibition of the circuit is anxiolytic and blocks hyperglycemia induced by restraint stress. Pharmacogenetic inhibition of the ARC(Gad2+)-->raphe obscurus nucleus (ROb) and photoactivation of the aBNST(Gad2+)-->ARC circuits simultaneously leads to significant hypoglycemia and anxiety-like behavior. Pharmacogenetic inhibition of the ARC(Gad2+)-->nucleus of the solitary tract (NTS) whilst photoactivation of the aBNST(Gad2+)-->ARC circuit only induces hyperglycemia. Our results reveal that the aBNST(Gad2+)-->ARC(Gad2+)-->ROb circuit is recruited for the stress response of rapid glucose mobilization and the aBNST(Gad2+)-->ARC(Gad2+)-->NTS circuit for behavioral symptoms of stress response. This study identifies a possible general strategy for neurocircuitry structural organization dealing with multiple organs involved in responses, with potential therapeutic targets for emotion and energy metabolism disorders underlying psychiatric disorders. |
