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Allele : Sox17<tm2.1(icre)Heli> SRY (sex determining region Y)-box 17; targeted mutation 2.1, Heiko Lickert
Primary Identifier  MGI:4418897 Allele Type  Targeted
Attribute String  Recombinase Gene  Sox17
Transmission  Germline Strain of Origin  (C57BL/6J x 129S6/SvEvTac)F1
Is Recombinase  true Is Wild Type  false
molecularNote  The Sox17 translational stop codon in exon 5 was replaced by a T2A (Thosea asigna virus, TaV) self-cleaving peptide followed by the improved Cre (iCre) for the efficient and equimolar translation of Sox17 and icre. Sox17 and icre are postranslationally cleaved by a 2A-mediated ribosome-skipping mechanism. The FRT-flanked neo selection cassette was subsequently deleted in the germline by FLP-mediated recombination.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Sox17- 2Aicre,
  • Sox17<tm2.1(icre)Lic>,
  • Sox17<2A-iCredeltaneo>,
  • Sox17-2A-iCre,
  • Sox17- 2Aicre,
  • Sox17<2A-iCre>,
  • Sox17<2A-iCre>,
  • Sox17<tm2.1(icre)Lic>,
  • Sox17-2A-iCre,
  • Sox17<2A-iCredeltaneo>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

1 Driven By

21 Publication categories





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