| Primary Identifier | MGI:4420244 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Thy1-APPSwe)1Lngn |
| Strain of Origin | (C57BL/6 x CBA)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A human amyloid beta (A4) precursor protein cDNA sequence (APP695) was altered to include the APP KM670/671NL (Swedish) Familial Alzheimer's Disease (FAD) mutation. The resultant APPSwe construct was then placed downstream of the mouse thymus cell antigen 1, theta [Thy1] promoter (via insertion into the ATG start site in exon 2 of the mouse Thy1 locus in the Thy-1323-cassette). The resulting transgene was microinjected into (C57BL/6xCBA)F1 pronuclear oocytes. Two founder lines were generated and one line displaying 3-fold overexpression of human APP in the brain was analyzed further. |
