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Allele : Igh-J<tm1.1Lave> immunoglobulin heavy chain, joining region; targeted mutation 1.1, Laurent Verkoczy
Primary Identifier  MGI:4421672 Allele Type  Targeted
Gene  Igh-J Transmission  Germline
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The human monoclonal antibody 2F5 was targeted into the J region removing J1 through 4 to produce chimeric human/mouse 2F5 antibodies. A floxed neo cassette used for ES cell selection was removed by cre mediated recombination. The 2F5 antibody is a polyreactive and broadly neutralizing antibody that protects against simian HIV challenge.
  • mutations:
  • Insertion,
  • Intergenic deletion
  • synonyms:
  • 2F5 VH<+>,
  • 2f5,
  • 2F5 VH<+>,
  • 2f5,
  • Igh-J<tm1.1(2F5)Lave>,
  • Igh-J<tm1.1(2F5)Lave>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

8 Publication categories





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